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Titel Antimicrobial activity of Manuka honey against antibiotic resistant strains of the cell wall free bacteria Ureaplasma parvum and Ureaplasma urealyticum
Subtitel
Author K. L. Hillitt, R. E. Jenkins, O. B Spiller, M. L. Beeton
Abstract The susceptibility of the cell-wall free bacterial pathogens Ureaplasma spp. to Manuka honey was examined. The minimum inhibitory concentration (MIC) of Manuka honey for four Ureaplasma urealyticum and four Ureaplasma parvum isolates was determined. Sensitivity to honey was also compared to clinical isolates with resistance to tetracycline, macrolide and fluoroquinolone antibiotics. Finally step-wise resistance training was utilised in an attempt to induce increased tolerance to honey. The MIC was dependent on the initial bacterial load with 7.5% and 18.0% w/v honey required to inhibit U. urealyticum at 1 and 106 colour changing units (CCU), respectively, and 4.8% and 15.3% w/v required to inhibit U. parvum at 1 and 106 CCU, respectively. MIC values were consistently lower for U. parvum compared with U. urealyticum. Antimicrobial activity was seen against tetracycline resistant, erythromycin resistant and ciprofloxacin resistant isolates at 105 CCU. No resistance to honey was observed with fifty consecutive challenges at increasing concentrations of honey. This is the first report of the antimicrobial activity of Manuka honey against a cell-wall free bacterial pathogen. The antimicrobial activity was retained against antibiotic resistant strains and it was not possible to generate resistant mutants.
Methods
Results
Conclusions
dx.doi.org / URL
Published 
Letters in Applied Microbiology
Titel Royal Jelly Protects Heart from Chemotherapy Damage 
Subtitel Cardioprotective effect of royal jelly on paclitaxel-induced cardio-toxicity in rats
Author Malekinejad, Ahsan, Delkhosh-Kasmaie, Cheraghi, Rezaei-Golmisheh, Janbaz-Acyabar.

Weiterlesen: Malekinejad, Ahsan, Delkhosh-Kasmaie,...

Titel Saudi Propolis May Help Treat Malaria 
Subtitel In vivo assessment of the antimalarial and spleen-protective activities of the Saudi propolis methanolic extract
Author Qwait AlGabbani, Lamjed Mansour, Yasser A. Elnakady, Saleh Al-Quraishy, Suliman Alomar, Esam M. Al-Shaebi, Abdel-Azeem S. Abdel-Baki

Weiterlesen: Qwait AlGabbani, Lamjed Mansour, Yasser A....

Titel Different Honeys Differ Greatly in Immunostimulatory Activity
Subtitel Correlation of the immunostimulatory activities of honeys with their contents of identified bioactives
Author Swapna Gannabathulaa, Geoffrey W. Krissansena, Liana Bisson-Rowea, Margot Skinnerb, Gregor Steinhornc, Ralf Schlothauerc
Abstract Honeys with unique compositions and properties are worth studying for their health-promoting effects. In order to correlate bioactive content with immunostimulatory activity we compared the abilities of seventy eight New Zealand and non-New Zealand honeys to stimulate blood monocytes to release tumour necrosis factor (TNF)-α, and examined the compositions of selected honeys that had widely varying activities.

 All the honeys, except for a Malaysian "Amber honey" stimulated the release of TNF-α from monocytes. However, the honeys differed greatly in their immunostimulatory activity, even within the same honey type. They differed in their contents of immunostimulatory components, including apalbumins, arabinogalactan proteins, and apisimin, whose levels did not correlate exactly with immunostimulatory activities.

 We suggest that the immunostimulatory properties of honey may be influenced by other factors, including unidentified immunostimulatory bioactives and immunosuppressive components; the bioavailability of some bioactives may depend on unidentified factors.
Methods
Results
Conclusions
dx.doi.org / URL http://dx.doi.org/10.1016/j.foodchem.2016.10.038
Published  Food Chemistry - Volume 221, 15 April 2017, Pages 39–46

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